The rapid development of information technology leads to qualitative and quantitative increase in new challenges and threats related to the information domain. Their transboundary nature predetermines the ongoing expansion of international cooperation in this area, including activities within the Collective Security Treaty Organization. In this regard, the work objective is to make a systemic study of the collective mechanisms for ensuring information security in the framework of the CSTO in the context of global eff orts in this area. The CSTO implements a comprehensive response to challenges and threats to information security. Member states develop agreed positions, coordinate their participation in existing global negotiation formats. The CSTO Secretariat staff representatives are present at relevant international venues. Joint steps are being prepared with other regional organizations. Political interaction is complemented by joint practical work of law enforcement agencies and special services based on institutionalized cooperation mechanisms. The legal and organizational foundations have been laid for countering hostile cyber actions (Consultative Coordination Center for Response to Computer Incidents), conducting joint special operation (“PROKSI”), combating crime, and training personnel. However, in the current international situation, the growing needs for ensuring information security require expanding cooperation beyond current political and practical interaction. As states become ready, it seems relevant to develop collective measures and coordinate international cooperation based on the concept of cognitive security.