The article deals with the consequences of the vulnerability of cultural codes as an actual threat to the existence of human civilization with the uncontrolled and unreasonable use of artifi cial intelligence. Positive as well as negative options for the interaction of artifi cial intelligence with cultural codes that level the understanding of the basic universals of human behavior, communication, and activity are analyzed. The influence of the human factor on the use of acquired skills by strong artifi cial intelligence in non-standard conditions, the responsibility of a particular specialist for the quality and quantity of input data under the infl uence of his gender, confessional, national, racial, cultural and linguistic characteristics, leading the system to erroneous actions and conclusions, are investigated. The negative consequences of an uncritical perception of reality, the inability of a modern person to distinguish content from fakes that are becoming massive, replacing the existing reality, used for unseemly and criminal purposes are considered. The necessity of state regulation of the ethical behavior of business engaged in the development and implementation of artifi cial intelligence technologies, the establishment of ethical behavior standards in this innovative area, the signing of the Code of Ethics of Artifi cial Intelligence, adopted by representatives of leading domestic companies, are substantiated. The practical implementation of the areas of training of highly qualifi ed IT specialists presented in it at universities, the system of additional education with the acquisition of demanded professions of specialists in data analysis and processing, ensuring the operation of corporate information systems, data analysis in the fi eld of education, programmers, including at the Saratov National Research State University named after N.G. Chernyshevsky, Saratov State University of Genetics, Biotechnology and Engineering named after N. I. Vavilov.